The shift in health care services from hospital-based to community- and home-based care, often provided by family members, exacts a significant emotional and physical toll on both patients and caregivers, an experience known as caregiver fatigue, caregiver strain, or caregiver burden. The Zarit Burden Interview (ZBI) and the Short Form Zarit Burden Interview (ZBI-12) were used to assess caregiver burden in 10 patients with lower extremity amputation who presented with a caretaker over a 3-month period.