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Original Contribution
Below-the-Ankle Interventions for Chronic Limb-Threatening Ischemia: Safety and Efficacy in an Office-Based Practice

The study objective was to evaluate the safety and efficacy of below-the-ankle intervention in the office-based setting for treatment of chronic limb-threatening ischemia.

Original Contribution
Outcomes Among Patients With Chronic Critical Limb Ischemia With No Revascularization Option: Systematic Review and Meta-Analysis

Two prespecified literature searches were conducted via Ovid utilizing the following databases: MEDLINE, EMBASE, and Cochrane Database of Systematic Reviews (CDSR). We selected studies reporting amputation-free survival (AFS) in patients with non-revascularizable Rutherford category 5/6 CLI at a minimum follow-up of 6 months.

Original Contribution
Comparison Between Intra-Arterial Carbon Dioxide and Iodinated Contrast Agent Injections in Patients With Lower-Limb Peripheral Arterial Diseases and Mild-to-Moderate Renal Dysfunction: A Randomized Controlled Trial

This randomized, controlled trial was designed to compare the rate of postangiographic contrast-induced nephropathy between the intra-arterial injections of carbon dioxide and the iodinated contrast agent.

Original Contribution
Cost-Effectiveness of Percutaneous Deep Vein Arterialization for Patients With No-Option Chronic Limb-Threatening Ischemia: An Exploratory Analysis Based on the PROMISE I Study

Our study objective was to explore the potential cost-effectiveness of treatment with the LimFlow pDVA system (LimFlow SA) in the United States healthcare system.

Review
Orbital Atherectomy Treatment of Peripheral Artery Disease and Critical Limb Ischemia

We review here the mechanism of action of OA, supporting clinical study evidence, and corresponding economic analyses.

Original Contribution
Chronic Total Occlusions: Association Between Characteristics and Mid-Term Outcomes in Critical Limb Ischemia

Despite medical advancements, PAD and CLI continue to increase globally. Treatment for PAD/CLI varies widely and patients with CTOs may be more challenging to treat, requiring specialized crossing techniques and modalities. The objective of this study was to determine the relationship between patients diagnosed with PAD/CLI, with CTOs, and subsequent long-term outcomes.